What is EGCG and What Can It Do for Health?
What is EGCG and What Can It Do for Health?
EGCG is getting tons of attention lately for its science-backed antioxidant effects. Researchers have discovered thatEGCG can help fight cancer, support heart and skin health, and aid weight loss, among other things.
The potential health benefits ascribed to green tea and EGCG include antioxidant effects, cancer chemoprevention, improving cardiovascular health, enhancing weight loss, protecting the skin from the damage caused by ionizing radiation, and others. (Nagle, et. al.)
Article jumplinks:
Chemical structure and classification
What are other sources of EGCG?
Antioxidant properties of EGCG
Can EGCG protect heart health?
Can EGCG help with weight loss?
EGCG’s powerful antioxidant capacity is key to matcha's overarching benefits for health and longevity. A single cup of matcha green tea can provide you with a much higher dose of EGCG than regular green tea. It's like giving your body a superhero boost of antioxidants with every sip.
Power up with our mushroom matcha tea—a harmonious marriage of matcha and cordyceps mushrooms. Every creamy sip serves up antioxidants, immunity boosters, and stress relievers for whole body wellness.
What Is EGCG?
Epigallocatechin gallate, or epigallocatechin-3-gallate (EGCG), is a potent compound that comes from the catechin family, a class of natural polyphenols found in the Camellia sinensis plant. Camellia sinensis gives us an array of green teas, such as matcha, black tea, white tea, and oolong tea.
We have a lot to explain about this matcha’s amazing antioxidant. Let’s start with its chemical composition and what makes EGCG the most powerful polyphenol in green tea.
Chemical Structure and Classification of EGCG
EGCG is a flavonoid, a type of polyphenol, with the chemical formula C22H18O11. It contains gallic acid and epigallocatechin moieties linked by ester bonds. More specifically, EGCG is the ester of epigallocatechin and gallic acid.
An ester is a compound formed when an acid reacts with an alcohol, removing a water molecule in the process. In this case, epigallocatechin is the “alcohol” compound, which contains multiple hydroxyl groups, while gallic acid is the “acid” compound, which contains carboxyl groups.
When these two compounds react, the hydrogen from the carboxyl group bonds with the hydroxyl group, forming an ester bond. This binds epigallocatechin and gallic acid together into a more stable structure called EGCG.
Chemical structure of EGCG. Source:
https://pubchem.ncbi.nlm.nih.gov/compound/Epigallocatechin-Gallate
As we mentioned earlier, EGCG is a type of catechin, which is a subgroup of flavonoids, and flavonoids are a subgroup of polyphenols. Too complicated? Let’s break it down before we dig deeper into EGCG.
- Polyphenols are a large, diverse group of micronutrients with potent antioxidant properties that may help keep you healthy and protect against diseases. They act as antioxidants by donating electrons to neutralize free radicals, fight oxidative stress, and prevent cellular damage.
- Flavonoids are the largest and most studied subgroup. There are six major subclasses of flavonoids: flavonols, flavones, isoflavones, flavanones, anthocyanins, and flavanols (also called catechins). These all share a common 3-ring C6-C3-C6 structure.
- Catechins are a specific family of flavonoids found abundantly in teas, cocoa, wine, and some fruits. The four major catechin compounds are epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC), and epigallocatechin gallate (EGCG). Green tea catechins are responsible for the bitter taste of green tea, matcha, and other Camellia sinensis derivatives.
- Epigallocatechin gallate, or epigallocatechin-3-gallate (EGCG), is the most abundant and powerful catechin. The catechol and gallate chemical groups in EGCG's structure contribute to its potency as an antioxidant. The previously mentioned ester bonds between epigallocatechin and gallic acid in EGCG make it a very stable antioxidant compound.
Source:
https://www.mdpi.com/2072-6643/4/11/1679
As a catechin, a flavonoid, and a polyphenol, EGCG is considered the most abundant and potent antioxidant due to its powerful health benefits. Compared to other catechins in green tea, EGCG also has superior bioavailability thanks to its distinct chemical structure. In other words, EGCG is more readily absorbed and utilized by the body than other polyphenolic compounds such as EGC and ECG.
But not all green teas contain the same high levels of EGCG. Matcha green tea stands out as an incredibly rich source of EGCG compared to other green teas.
Our matcha tea powder contains premium ceremonial grade matcha, delivering an abundance of antioxidants. The combination of organic cordyceps mushrooms and matcha powder provides powerful adaptogenic benefits to help the body handle stress and increase energy.
Whisk up your frothy blend for improved vitality with our mushroom matcha box.
How Much EGCG Is in Matcha?
Matcha is a powdered green tea extract with a vibrant green color, a unique, earthy flavor, and an exceptionally high nutritional profile. Also called Japanese tea or jade leaf tea, matcha is made from the entire tea leaf of the Camellia sinensis plant pulverized into a fine powder. Consuming the whole leaf allows for much higher levels of antioxidants, especially EGCG.
A 2003 research article showed that the amount of catechins in matcha is much higher than in regular green tea.
…the mean levels of the total catechins, (−)-epigallocatechin 3-gallate, (+)-catechin, and caffeine were found to be very similar in [15 Chinese green tea and 13 Japanese green], but other minor catechins such as (−)-epigallocatechin, (−)-epicatechin, and (−)-gallocatechin 3-gallate were found to be higher in Japanese green tea products…
Other studies have confirmed these numbers. Matcha may contain three times more antioxidants and as much as 137 times more EGCG than low grade green teas.
Using a mg catechin/g of dry leaf comparison, results indicate that the concentration of epigallocatechin gallate (EGCG) available from drinking matcha is 137 times greater than the amount of EGCG available from China Green Tips green tea, and at least three times higher than the largest literature value for other green teas.
According to this article, a 3oz serving of matcha contains approximately 242 mg of catechins. In comparison, an 8oz cup of brewed green tea provides around 188 mg of catechins. Matcha has also been found to contain approximately 17.5 mg of EGCG per gram of powder. Regularly brewed green tea only contains around 0.05mg of EGCG per gram of dry leaf.
So matcha generally contains the highest amount of EGCG. This is the result of using the whole leaf and special shading techniques. The tea bushes that produce matcha are shaded for 3–4 weeks before harvest. This shading triggers increased production of EGCG, amino acids, and other compounds as the plant tries to absorb more sunlight.
Matcha leaves are harvested just before peak maturity. Younger leaves contain higher levels of EGCG, chlorophyll, and L-theanine compared to older leaves used in other green teas.
L-theanine is an amino acid in matcha that can provide anti-anxiety and cognition-enhancing effects. Research suggests that, when consumed together, EGCG and L-theanine may have synergistic effects on health, particularly on protecting and repairing nerve cells.
The synergistic mechanism study showed that under the premise that EGCG inhibits amyloid stress and inflammation and promotes metabolism, l-theanine could play a nourish nerve effect. EGCG + l-theanine keeps differentiated nerve cells in a quiescent state, which is beneficial to the repair and regeneration of nerve cells. In addition, EGCG + l-theanine maintains the high-fidelity structure of cellular proteins.
That’s another excellent reason to drink matcha tea every day. If not for the delicious, earthy taste, then for the abundance of antioxidants, amino acids, and other beneficial compounds that propel your health to new heights.
Enjoy every sip of our matcha tea with Cordyceps militaris mushrooms. Did you know that cordyceps is a powerful anti-inflammatory agent that helps protect against diseases and fight cancer? Sipping this dynamic blend is a tasty way to power up your mind and body in a natural way.
Other Sources of EGCG
EGCG is predominantly found in green teas. The amount of EGCG in other foods is considerably lower than in matcha green tea.
You may be able to find trace amounts of epigallocatechin gallate in the following foods:
- Teas: green tea, matcha, oolong tea, white tea, black tea
- Fruits: cranberries, strawberries, blackberries, cherries, kiwis, apples, peaches, pears, apricots, pomegranates, and avocados
- Nuts: hazelnuts, pecans, and pistachios
- Beans: soybeans, kidney beans, and broad beans
- Wine
What Are the Health Benefits of EGCG?
The versatility of EGCG in targeting important biological pathways makes it a promising natural compound for the prevention and management of a wide range of health conditions. We’re breaking down the most important effects of EGCG:
- Antioxidant: EGCG neutralizes free radicals and protects cells from oxidative damage.
- Anti-inflammatory: it reduces inflammation by inhibiting inflammatory markers.
- Cancer prevention: EGCG may inhibit tumor growth and induce cancer cell death.
- Heart health: EGCG lowers low-density lipoprotein (LDL) cholesterol, improves blood flow, and reduces blood pressure.
- Brain health: it boosts cognition, focus, and mood and may help prevent Alzheimer's disease and the development of many neurodegenerative diseases.
- Weight management: EGCG significantly increases fat burning and helps regulate blood sugar and insulin levels for easier weight control.
- Anti-aging: EGCG combats aging factors like wrinkles, sun damage, and age spots.
- Oral health: EGCG reduces inflammation and bacteria for healthier gums and teeth.
As you can see, EGCG touches on almost every aspect of health. If you think this is impressive, wait until youlearn about the mechanisms behind these amazing therapeutic effects of EGCG.
EGCG Is the Most Active Antioxidant in Matcha
The antioxidant properties of EGCG are a key factor behind many of its health benefits. The main role of antioxidants is to neutralize free radicals and protect cells from oxidative stress.
Free radicals, or reactive oxygen species (ROS), are highly reactive molecules that our bodies produce as by-products of normal cellular processes like immune responses and metabolism. While small amounts of free radicals help in cell signaling and defense against pathogens, excessive production of ROS can lead to oxidative damage.
Sufficient amounts of antioxidants balance out the free radicals and prevent them from causing cellular damage. Our bodies produce some types of antioxidants naturally, but the majority of them come from food and dietary sources. One of the richest sources of antioxidants is green tea, particularly matcha, with its high EGCG content.
The reason EGCG is a powerful antioxidant is because of its unique chemical structure. It contains multiple electron-rich structures that can donate electrons to free radicals, rendering them less harmful to our cells.
Studies have found that EGCG’s antioxidant activities upregulate the body's innate antioxidant defense systems. EGCG activates the Nrf2 signaling pathway, which induces the production of endogenous antioxidants and protective enzymes.
A 2022 review titled Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate suggests that “the majority of the mentioned pathways can be modulated by EGCG, which thereby alleviates inflammation and cell proliferation.”
…Nrf2 acts in de novo synthesis of antioxidant enzymes protecting from cytotoxicity caused by oxidative stress, or pro-inflammatory mediators. Another antioxidant system activated by Nrf2 is heme oxygenase (HO)-1. HO-1 is an enzyme responsible for degradation of heme to carbon monoxide (CO), free iron and biliverdin-IXα. Since biliverdin-IXα is converted to bilirubin-IXα, an endogenous scavenger of radicals, iron is sequestered into ferritin which together with CO exert antioxidant and anti-apoptotic effects. EGCG induced expression of both Nrf2 and HO-1, which resulted in antioxidant and anti-inflammatory effects.
Source:
https://www.mdpi.com/2076-3921/11/8/1566
We can’t talk about EGCG’s powerful antioxidant properties without mentioning its mighty anti-inflammatory action. Because of the abundance of EGCG, matcha is highly effective in reducing inflammation.
Anti-inflammatory Properties of EGCG
Oxidative damage can cause a wide range of chronic ailments in the body, including inflammation. By neutralizing free radicals, EGCG helps reduce inflammation.
Inflammation is the body’s natural defensive response to harmful stimuli like damaged cells, injuries, toxins, or pathogens. While acute inflammation is normal and beneficial, chronic inflammation can lead to serious tissue damage and disease.
Inflammation also generates reactive oxygen species that cause oxidative stress. By neutralizing ROS, antioxidants like EGCG counteract oxidative damage and help suppress chronic inflammation, which can amplify the inflammatory response.
In one study, rats with spinal cord injuries were treated with epigallocatechin gallate. They showed reduced activity of myeloperoxidase (an indicator of inflammation). A treatment with EGCG also led to decreased expression of inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and others.
Based on the findings, the study suggests that EGCG’s anti-inflammatory properties “may be effective in protecting rat spinal cord from secondary damage by modulating the inflammatory reactions.”
EGCG for Cancer Prevention
EGCG's anticancer properties have shown great potential in laboratory studies and animal models. While more research is needed before definitive conclusions can be drawn for human cancer prevention and treatment, there’s no doubt that EGCG exhibits promising anti-tumor and chemopreventive activities.
Here's what we currently know about the potential role of EGCG in combating cancer:
- EGCG fights oxidative damage and lowers inflammation. Both are known as risk factors for cancer development.
- EGCG has been shown to interfere with important cellular processes involved in cancer cell growth and proliferation. It can inhibit the activity of specific enzymes and signaling pathways that promote cancer cell division, thus slowing down tumor growth.
- EGCG induces apoptosis, a natural process of programmed cell death, in cancer cells. This makes it an attractive potential cancer treatment that does not cause significant harm to healthy cells.
- EGCG can also interfere with the formation of new blood vessels that supply tumors with nutrients and oxygen, formally known as angiogenesis. Angiogenesis is critical for tumor growth and metastasis, and by inhibiting the formation of new blood vessels, EGCG can help starve tumors and limit their spread.
A 2012 study showed that EGCG has potent chemopreventive effects on prostate, breast, lung, and colorectal cancers.
Among the 10 polyphenols, EGCG showed the most potent antiproliferative effects, and significantly induced cell cycle arrest in the G1 phase and cell apoptosis… The antiproliferative effect of EGCG is even more potent than 5-fluorouracil, which is a chemotherapy drug on colorectal cancer.
Proliferation is the rapid growth and division of cells. Uncontrolled proliferation is a hallmark of cancer, allowing tumors to grow and spread. EGCG was found to potently inhibit the proliferation of cancer cells by inducing apoptosis and arresting the cell cycle to prevent uncontrolled division.
EGCG shows potential as a beneficial adjunct in lung cancer treatment. It targets receptor tyrosine kinases (EGFR and c-Met), inhibiting cell growth and migration in lung cancer cells. It may also enhance the effectiveness of standard anticancer agents and could be combined with other polyphenols to improve its impact on tumor cells.
While low concentrations of EGCG (plasma levels of ≤10 µM) have demonstrated antioxidant action and amelioration of insulin resistance, high concentrations of EGCG (>10 μM) may act as a pro-oxidant agent enhancing autophagy and cell death, and thereby may be utilized, e.g., in the treatment of tumors. (Mokra, et. al.)
EGCG may also be beneficial in enhancing the effectiveness of certain cancer therapies, such as chemotherapy and radiation therapy.
We know another all-around amazing anticancer agent, and we just so happen to have combined it with matcha in our fragrant cordyceps matcha tea.
The bioactive compounds of cordyceps mushrooms exhibit anti-tumor effects by inhibiting cancer cell proliferation, inducing apoptosis, and modulating immune responses. This way, cordyceps is a useful ally for potential cancer prevention.
Want to learn more about these phenomenal fungi? Our in-depth guide uncovers the beneficial effects of Cordyceps militaris.
EGCG to Protect the Heart
Many bioactive compounds in matcha have cardioprotective properties—L-theanine, chlorophyll, vitamins, and minerals—but none are as effective as epigallocatechin-3-gallate. Packed with antioxidant and anti-inflammatory properties, EGCG may exert protective effects on the heart muscle. By fighting oxidative stress and reducing inflammation, it helps prevent cardiac inflammatory changes.
EGCG may potentially exert a protective effect on the heart muscle in patients undergoing surgery who are susceptible to ischemic injury, by inhibiting the activation of stress-activated protein kinase and signalling pathways inducing the inflammatory response. (Kochman, et. al.)
Studies have found that EGCG can keep the heart healthy and strong by:
- Reducing blood pressure
- Lowering LDL cholesterol
- Preventing plaque buildup in the arteries
- Improving vascular flexibility and relaxing blood vessels
- Modulating lipid metabolism
- Boosting blood flow
Huang, et. al. looked at the effects of EGCG on mice with coronary heart disease (CHD). The mice with CHD showed heart tissue damage and an imbalance in blood lipid levels (cholesterol and triglycerides). After treatment with EGCG, their heart tissue damage improved, the levels of high-density lipoprotein (HDL) cholesterol increased, and ROS activity significantly decreased.
According to Huang, et. al., “EGCG might inhibit atherosclerosis in mice with CHD.” Inflammation and free radicals often lead to fatty deposits in blood vessels, or atherosclerosis, which is a key risk factor for cardiovascular disease. By improving blood lipid levels and increasing the activity of an antioxidant enzyme called superoxide dismutase (SOD), EGCG helped protect the heart tissue from damage.
Kasper, et. al. suggested that EGCG supplementation may alleviate inflammatory complications after the use of cardiopulmonary bypass (CPB) for major cardiac surgery, including lung injury and dysfunction. The study results revealed that “EGCG appears to attenuate CPB-associated lung injury,” likely due to its anti-inflammatory and antioxidant properties.
EGCG to Protect the Brain
EGCG is good for the brain, too. It has promising neuroprotective effects and can promote cognitive function. We’ve been on and on about how harmful oxidative damage is, but there’s evidence that an excessive amount of free radicals can contribute to neurodegenerative diseases like Alzheimer’s and dementia that lead to cognitive impairment and poor mental health.
One way EGCG fights cognitive impairment is by protecting our neurons from beta-amyloid and tau proteins. These neurotoxic substances are involved in the development of Alzheimer’s disease by accumulating in the brain and forming plaques that damage and kill neurons.
The good news is that EGCG prevents that accumulation, reducing the neuron-damaging effects of these toxins. In one study, both intraperitoneal injection and oral administration of EGCG successfully reduced the deposition of beta-amyloid in the brain.
We previously reported that intraperitoneal (i.p.) injection (20 mg/kg) of (-)-epigallocatechin-3-gallate (EGCG)... decreased beta-amyloid (Abeta) levels and plaques via promotion of the non-amyloidogenic alpha-secretase proteolytic pathway in "Swedish" mutant amyloid precursor protein overexpressing (APPsw, Tg) mice. Here, we find that EGCG administered orally in drinking water (50 mg/kg) similarly reduces Abeta deposition in these mice. (Rezai-Zadeh, et. al.)
The study found that “EGCG dietary supplementation [may be] a potentially safe and effective prophylaxis for Alzheimer's disease.” For Alzheimer's patients, this means less neuronal damage and reduced cognitive decline.
Besides the effect on neurodegenerative diseases, EGCG is shown to inhibit the microglia mediated inflammatory response and reduce the damage of the central nervous system triggered by infrasound. (Chu, et. al.)
Infrasound is a type of low-frequency noise found in the environment that can cause damage to the central nervous system and lead to health issues. Researchers have recently discovered that epigallocatechin gallate may have the potential to reduce that damage.
In their study on rats exposed to infrasound, Chu, et. al. found that EGCG reduces the activation of microglia (immune cells in the brain) and decreases the production of harmful inflammatory substances. EGCG prevented the cell death and damage that would normally occur due to increased inflammation. Thanks to its protective effects, the neurons remained intact despite infrasound-induced toxicity.
Can EGCG Help Me Lose Weight?
Many believe that matcha's caffeine kick is the driver of its metabolism-boosting effect. Move over, caffeine. The real secret weapon in matcha for weight loss is EGCG. This potent antioxidant is your new best friend when it comes to boosting your metabolism and helping you burn calories faster.
Research shows that EGCG and other green tea catechins have the remarkable ability to enhance fat burning. This process starts by influencing fat-fighting hormones like norepinephrine that help mobilize stored fat, breaking it down into free fatty acids. EGCG activates the key enzyme, called hormone-sensitive lipase, that unlocks those fat cells so their contents can enter your bloodstream.
Once the broken-down fat is circulating in the blood, the catechins come in again to ramp up your metabolism. The result? Your body is now primed to torch that fat for fuel and energy, not store it. Boschmann and Thielecke propose that “EGCG alone has the potential to increase fat oxidation in men and may thereby contribute to the anti-obesity effects of green tea.”
It seems that matcha’s EGCG can reduce weight gain and adipose tissue (fat) weight by reducing calorie intake and activating a protein called AMPK in the liver, skeletal muscle, and fat tissues.
Researchers also found that EGCG changed the expression of genes involved in fat metabolism, promoting fat breakdown and inhibiting synthesis in fat tissues.
EGCG inhibited the expression of genes involved in the synthesis of de novo fatty acids and increased the expression of genes associated with lipolysis and lipid oxidation in epididymal adipose tissues... In subcutaneous adipose tissues, some adipogenic genes were significantly upregulated at the mRNA level by EGCG compared with the HFD group, but not at the protein level.
The conclusion was that “EGCG had significant positive effects on obesity and epididymal fat accumulation in mice." The activation of AMPK increased in the fat tissues, but it was only partially responsible for EGCG's weight-reducing effects.
Another study showed that EGCG reduces fat accumulation in a dose-dependent manner without affecting food intake or physical activity. It was observed that EGCG might also inhibit adipogenesis (the formation of new fat cells) and reduce overall fat content in Caenorhabditis elegans (C. elegans), a type of roundworm.
While EGCG shows promise in supporting weight loss efforts, this potent catechin alone is unlikely to lead to significant weight loss without the combination of a balanced diet, regular physical activity, and a healthy lifestyle.
We can’t think of anything healthier than our cordyceps tea with matcha. Sip matcha tea loaded with EGCG and fat-burning cordyceps mushrooms to really stoke your metabolic fire.
Anti-Aging Properties of EGCG
As a powerful antioxidant, EGCG helps neutralize free radicals that can damage skin cells and accelerate the aging process. EGCG is highly effective at protecting the skin against premature aging.
Research shows that green tea polyphenols, specifically EGCG, provide the most protection against skin inflammation and immunosuppression caused by UVB radiation from the sun. EGCG seemed to be the most effective green tea polyphenol at defending against UVB-induced contact hypersensitivity and inflammatory responses in the skin.
Among the four major epicatechin derivatives present in [green tea polyphenols], (-)-epigallocatechin-3-gallate, the major constituent, was found to be the most effective in affording protection against UVB-caused CHS and inflammatory responses.
UVB radiation from sunlight can damage the skin and accelerate aging. It generates reactive oxygen species that, aside from causing oxidative stress and inflammation, can also lead to structural changes in the skin’s collagen and elastin.
Speaking of collagen, EGCG seems to stimulate collagen synthesis. Collagen is a protein that provides structure and elasticity to the skin. As we age, collagen production decreases, which often leaves our skin wrinkled and saggy. By stimulating collagen, our skin can regain elasticity and reduce the appearance of wrinkles.
The anti-aging properties of matcha’s EGCG make it a promising ally in the pursuit of youthful and radiant skin. With regular use, matcha and its EGCG content can improve skin tone, reduce wrinkles, and slow down the aging process, allowing you to maintain a vibrant and healthy complexion.
So go ahead and indulge in a delicious cup of matcha tea, knowing that you're not only treating your taste buds but also nurturing your skin. Choose between our two sizes of our delicious tea—a 10-serving mushroom matcha box and a 30-serving mushroom matcha jar—and get a healthy dose of EGCG and other skin-friendly bioactive compounds for a more youthful appearance.
EGCG For Oral Health
Did you know matcha is extremely beneficial for your oral health? The antioxidants galore in green tea are to be held accountable for matcha’s ability to reduce plaque and bacteria in the mouth, protect the gums and prevent gum disease, and fight tooth decay. More specifically, EGCG is an excellent source of protection against cavities, gingivitis, and periodontal disease.
Research shows EGCG inhibits oral bacteria, prevents adhesion to teeth and gums, reduces inflammation, and strengthens the bones that support the teeth.
…EGCG has been reported to inhibit sugar transport and acid production by lactate dehydrogenase. It has been suggested that catechins on a daily basis can effectively reduce dental caries and that use of green tea extract herbal mouthwash reduces the acidity of saliva and inhibits bacterial colonisation. (Vyas, et. al.)
A 2012 study confirmed that rinsing your mouth with green tea extract can reduce the amount of bacteria in the mouth and improve gum health.
Catechins should be considered right alongside of the better-known antioxidants like vitamins E and C as potent free radical scavengers and health-supportive for this reason. It has been suggested that green tea also promotes periodontal health by reducing inflammation, preventing bone resorption and limiting the growth of certain bacteria associated with periodontal diseases.
You see now why sipping matcha daily allows you to reap all these oral health benefits. The concentrated levels of cavity-fighting, gum-protecting EGCG in matcha make it a powerhouse for promoting healthy teeth and gums.
How Much EGCG Is Safe Daily?
While there are no official dosage recommendations for EGCG as a dietary supplement, research studies seem to indicate thatdoses between 200 and 800 mg of EGCG per day may offer health benefits.
A safe intake level of 338 mg EGCG/day for adults was derived from toxicological and human safety data for tea preparations ingested as a solid bolus dose. (Hu, et. al.)
A daily intake of 800 mg of EGCG or more may increase the blood levels of transaminases, which may cause liver damage. Hu, et. al. also suggest that “a safe upper limit is 338 mg EGCG per day from green tea extracts in capsule/tablet form.”
The amount of EGCG you get from matcha depends on how long you brew your tea and the quality grade of the matcha powder. There is about 17.5 mg of EGCG per gram of matcha powder. Following typical dosage recommendations of 3–4 grams of matcha per day, you would end up consuming around 52.5–70mg of EGCG.
So just one simple cup of properly prepared matcha can provide you with a hefty amount of the powerful antioxidant EGCG. Our convenient 10-pack of matcha and cordyceps contains 3.5 grams of premium matcha blend per packet. You can mix the entire contents of one packet into a single cup for a mega-dose of catechins and adaptogens. Or divide it into multiple cups throughout the day.
For even more matcha goodness, try our 30-serving jar. Each teaspoon contains approximately 3 grams of our fine powder. Use one or two teaspoons per cup, depending on how strong you like your tea.
Side Effects of EGCG
Excessive amounts of EGCG, whether consumed through concentrated supplements or green tea, may lead to potential side effects. Some people may experience nausea, stomach upset, or diarrhea when taking large doses of EGCG.
These high doses may also interfere with iron absorption in the body, which may be concerning for people with iron deficiency or anemia.
EGCG from green tea and green tea extracts is widely used in traditional Chinese medicine, so it is considered safe even in huge dosages (>1–3 g per day). It can be a pro-oxidant bringing negative effects such reactive oxygen species (ROS) production. Despite this dichotomic effect, to date no studies confirmed the negative effect of EGCG in humans. (Cione, et. al.)
EGCG can also interact with certain medications and affect their effectiveness. If you are taking medications, consult your healthcare provider before taking EGCG supplements.
Do You Want to Consume EGCG Naturally?
Matcha is exploding in popularity for all the good reasons. One of them is the bounty of EGCG.
Hone's matcha cordyceps tea harnesses this power of premium ceremonial matcha. It delivers abundant EGCG to neutralize harmful free radicals, boost immunity and cognition, and reduce inflammation.
Our organic matcha comes from an eco-friendly Japanese tea farm at the base of Mt. Fuji. The shaded growth method boosts EGCG levels in the leaves. Then the youngest, most tender leaves are stone-ground into a smooth powder that dissolves beautifully. That’s why choosing Hone matcha powder is a great way to reap all the matcha tea benefits.
Another great thing about matcha is that it is versatile. Mix the powder into hot or iced water, plant-based milk, smoothies, baked goods, or anything you like. The addition of cordyceps mushrooms complements the green tea with earthy notes to create a well-rounded and multi-faceted flavor profile.
However you choose to prepare it, our mushroom matcha tea powder makes it simple to reap the benefits of EGCG. Harness the power of this antioxidant and start boosting your health today.
EGCG FAQ
Does EGCG really work?
EGCG has shown promising effects in many research studies. Its potent antioxidant properties help combat oxidative stress and protect cells from damage. EGCG's ability to modulate cell signaling pathways has been linked to potential health benefits, including reducing inflammation, promoting heart health, supporting weight management, and potentially contributing to anti-aging effects.
Is taking EGCG safe?
In general, EGCG is considered safe when consumed in moderate amounts through dietary sources like matcha. However, taking EGCG in concentrated form or as a supplement may require caution. High doses may lead to potential side effects, such as an upset stomach,t or interfere with iron absorption.
If you’re pregnant or breastfeeding or have specific medical conditions or allergies, you should consult your healthcare provider before taking EGCG supplements.
What does EGCG do to the brain?
EGCG has shown many beneficial effects on the brain. Studies suggest that EGCG can protect brain cells from damage caused by oxidative stress and inflammation, potentially reducing the risk of neurodegenerative diseases like Parkinson's disease. EGCG's ability to enhance cell survival and inhibit the accumulation of harmful amyloid precursor proteins may also be relevant in the context of brain health.
How does EGCG help the brain?
EGCG exerts its neuroprotective effects through multiple mechanisms. It can inhibit the formation of harmful amyloid fibrils, reduce oxidative stress, and modulate cell signaling pathways associated with brain health. EGCG may also promote the growth of brain cells and support their survival.
These actions collectively contribute to EGCG's potential benefits in maintaining brain function and reducing the risk of neurodegenerative disorders.
Is EGCG a steroid?
No, EGCG is not a steroid. It is a polyphenolic compound belonging to the catechin class that is abundantly found in green tea, particularly matcha. Steroids are a distinct class of organic compounds that share a specific structure and have different functions in the body.
How much EGCG is bad for the liver?
The specific amount of EGCG that may be considered harmful to the liver varies among individuals and depends on factors such as overall health, medications taken, and the form of EGCG used. High doses of EGCG have been associated with liver toxicity in some cases.
To avoid potential adverse effects on the liver, it is essential to follow the recommended dosages and consult a healthcare professional if there are any concerns.
Does EGCG affect sleep?
EGCG is generally not associated with sleep disturbances. In fact, matcha contains L-theanine, an amino acid that may have a calming effect and contribute to improved sleep quality. However, consuming large amounts of caffeine-containing green tea close to bedtime may interfere with sleep for some individuals.
Does coffee have EGCG?
EGCG is primarily found in green tea, not coffee. While coffee contains other beneficial compounds, such as chlorogenic acid, it does not contain significant levels of EGCG. If you are looking to benefit from EGCG, consider making matcha a part of your daily routine.
Does EGCG cause anxiety?
EGCG itself is not known to cause anxiety. Green tea contains L-theanine, which may have calming properties and counteract the potential anxiety-inducing effects of caffeine. However, consuming excessive caffeine from green tea or other sources can lead to restlessness and anxiety in some individuals.
Resources
Nagle, D. G., Ferreira, D., & Zhou, Y. D. (2006, July 31).Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives. PubMed Central (PMC). https://doi.org/10.1016/j.phytochem.2006.06.020
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